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An enhanced CNS depressant effect may occur when carbetapentane is combined with other CNS depressants including skeletal Lioresal discount relaxants. Hypotension, profound sedation, coma, respiratory depression, or death may occur; examples of other CNS depressants can include skeletal muscle relaxants, like baclofen. Prior to concurrent use of buprenorphine in patients taking a CNS depressant, assess the level of tolerance to CNS depression that has developed, the duration of use, and the patient’s overall response to treatment.

Monitor patients for sedation or respiratory depression. Moderate Concomitant use of skeletal Lioresal discount relaxants with buspirone can result in additive CNS depression. Dosage adjustments of either or both medications may be necessary. Moderate Concomitant use of butorphanol with other CNS depressants, such as baclofen, can potentiate the effects of butorphanol on respiratory depression, CNS depression, and sedation. CNS depressants can potentiate the Lioresal discounts of cannabidiol. Dosage adjustments of the antihypertensive medication may be required Carbetapentane; Chlorpheniramine: Moderate COMT inhibitors should be given cautiously with other agents that cause CNS depression, including skeletal muscle relaxants, due to the possibility of additive sedation. Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine: Caution should be exercised during simultaneous use of these agents due to potential excessive CNS effects or additive hypotension.

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